Table 1.
Pre-Implant Characteristics | Total n= 1470 | Age < 60 years n=457 | Age=60-69 years n=520 | Age≥ 70 years n=493 | p-value |
---|---|---|---|---|---|
Demographic and behavioral characteristics | |||||
Age at implant (mean years) | 63.4±11.8 | 49.0±9.4 | 65.7±2.9 | 74.1±3.0 | < .0001 |
Male (%) | 82 | 75 | 83 | 88 | < .0001 |
Race (% white) | 75 | 55 | 83 | 86 | < .0001 |
Married at time of implant (%) | 73 | 53 | 79 | 85 | < .0001 |
> high school education (%) | 50 | 42 | 50 | 58 | < .0001 |
Currently smoking (%) | 11 | 22 | 10 | 4 | < .0001 |
Current alcohol abuse (%) | 15 | 25 | 13 | 8 | < .0001 |
Current drug abuse (%) | 2 | 7 | 1 | 0 | < .0001 |
Clinical characteristics | |||||
Primary cardiac diagnosis (%) | |||||
Ischemic cardiomyopathy | 58 | 40 | 67 | 38 | < .0001 |
Dilated cardiomyopathy | 38 | 56 | 29 | 32 | < .0001 |
Other | 4 | 4 | 4 | 4 | .76 |
Co-morbidities (%) | |||||
Diabetes | 44 | 38 | 51 | 43 | .0004 |
CVA | 8 | 7 | 10 | 7 | .16 |
Right heart failure (RVEF severe) | 19 | 23 | 17 | 18 | .27 |
Pre COPD | 18 | 18 | 17 | 19 | .82 |
Cancer | 13 | 12 | 15 | 12 | .22 |
NYHA class IV (%) | 76 | 75 | 79 | 75 | .21 |
Intra aortic balloon pump (%) | 26 | 27 | 26 | 25 | .79 |
Ventilator (%) | 5 | 7 | 4 | 3 | .01 |
ECMO (%) | 1 | 3 | 1 | 0 | .003 |
Dialysis (%) | 2 | 2 | 1 | 1 | .20 |
INTERMACS profile at implant (%) | |||||
1 | 11 | 15 | 11 | 7 | .0001 |
2 | 36 | 37 | 36 | 35 | .76 |
3 | 32 | 32 | 32 | 32 | .95 |
4 | 15 | 10 | 17 | 19 | .0003 |
5 | 3 | 2 | 3 | 4 | .26 |
6 | 2 | 2 | 1 | 2 | .44 |
7 | 1 | 1 | 1 | 1 | .49 |
Inotrope therapy (%) | 78 | 82 | 78 | 75 | .03 |
Implantable cardioverter defibrillator (%) | 85 | 82 | 87 | 87 | .02 |
Temporary circulatory support (%) | 15 | 18 | 16 | 13 | .07 |
MCS = mechanical circulatory support, CVA = cerebrovascular accident, COPD = chronic obstructive pulmonary disease, ECMO = extracorporeal membrane oxygenation
*Those patients who were ‘too sick’ have been included and assigned VAS=0 and physical dimensions as ‘extreme problems’