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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Pharm Res. 2014 Sep 16;32(3):1028–1044. doi: 10.1007/s11095-014-1515-z

Table 1.

Pharmacokinetic parameters after IV administration (1 mg / kg) of water-soluble CA4P or CA4 physically loaded in uncross-linked F127 PM or F127 PM peripherally cross-linked with ethylenediamine at 76% (X-F127 PM) (22.9 wt% CA4) to female BALB/c mice bearing 4T1-Luc tumors as described in Fig.10 (n = 6 mice / time point).

PK Parameters CA4P F127 PM X-F127 PM
AUClast (h*ng/mL) 2531 3709 3702
AUC0-∞ (h*ng/mL) 2560 3990 4217
MRT0-∞ (h) 1.7 4.5 8
t0.5 (h) 3.90 8.4 10.5
CL (L/h/kg) 0.39 0.25 0.24
Vss (mL/kg) 0.67 1.1 1.9