Fig. 1.

Schematic graph of PSA doubling times according to different intervals during the transient period from the diagnosis of CRPC until the end of anti-androgen withdrawal and PSA response during docetaxel chemotherapy. PSA, prostate-specific antigen; PSADT1, PSA doubling time calculated with the traditional interval from the first rise greater than the nadir during androgen deprivation therapy until androgen withdrawal; PSADT2, PSA doubling time from the initial rise after anti-androgen withdrawal until the start of chemotherapy; PSADT3, PSA doubling time during the total interval from the nadir until the start of chemotherapy.