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. 2015 Jan 27;24(2):114–119. doi: 10.1111/exd.12593

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© 2014 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PVRL1 is a target gene of the transcription factor p63. (a) chromatin immunoprecipitation experiments (ChIP)-qPCR of the two identified p63-binding regions (p63BS) in the PVRL1 genomic locus was performed in human primary keratinocytes (upper panel) and in mouse epidermis (lower panel). (b) p63BS2 enhancer activity was analysed by luciferase assay in p63 depleted or control keratinocytes (*P-value = 3.12E-06; n = 6). Data are represented as mean of ± SD of three independent experiments.