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. 2014 Aug 18;69(10):1412–1419. doi: 10.1111/all.12472

Figure 4.

Figure 4

The expression of IL-4, IL-10, IL-13, IFN-γ, NK1.1, E4 promotor-binding protein 4 (E4BP4), and FOXP3 mRNA in the spleen (A) and skin (B) from NC/Nga mice. Real-time RT-PCR was utilized to evaluate the expression levels of IL-4, IL-10, IL-13, IFN-γ, NK1.1, E4BP4, and FOXP3 mRNA in the spleen from the conventional condition Plasmoduim berghei (Pb) XAT NC/Nga mice and the conventional uninfected NC/Nga mice. The levels of mRNA are presented relative to the gene expression of GAPDH and are shown by comparing the data of the SPF-uninfected mice. Data are mean ± SD of three different mice. The expression of IL-4, IL-10, IL-13, and IFN-γ mRNA in the spleen was increased at the early stages of infection. In contrast, the expression of NK1.1, E4BP4, and FOXP3 decreased. The expression of mRNA in the skin showed results opposite to that of the spleen. *P < 0.05, **P < 0.01.