Fig. 8.

Ectopic DGCs from rodent SE tissue exhibit a moderate, but significant, increase in excitability compared with normotopic DGCs. Both normotopic and ectopic DGCs born after SE exhibit more excitability than age-matched DGCs from sham-treated animals. All cells in the sham group were low-firing cells, so only cells from SE-treated animals were included for comparison of firing frequency. The solid black and gray lines were generated by fitting the respective scatter plot data with a Poisson regression line that passes through the origin. The slope of the line for ectopic DGC firing (0.032 ± 0.0038) is significantly different from the slope of the line for normotopic DGC firing (0.017 ± 0.0014; P < 0.0001, extra sum of squares F-test).