Table 3. P-values of 4-Way ANOVA of Medium, Microencapsulation (μB), Culture Time (Time) and Passage Number (Passage).
| Medium | μB | Time | Passage | μB × Medium | μB × Time | μB × Passage | |
|---|---|---|---|---|---|---|---|
| mRNA Levels | |||||||
| Acan/Rps18 | *<0.001 | 0.822 | 0.328 | 0.128 | 0.058 | 0.453 | 0.217 |
| Col2/Rps18 | 0.180 | *0.001 | 0.853 | *0.006 | 0.638 | 0.962 | 0.101 |
| Col10/Rps18 | *<0.001 | *<0.001 | 0.172 | *0.003 | 0.524 | 0.546 | 0.673 |
| Comp/Rps18 | *<0.001 | *0.001 | 0.339 | 0.198 | 0.580 | 0.720 | 0.299 |
| Fgf2/Rps18 | *<0.001 | *<0.001 | 0.931 | *0.070 | 0.074 | 0.544 | 0.831 |
| Igf1/Rps18 | *0.022 | *<0.001 | 0.546 | 0.612 | 0.537 | 0.893 | 0.978 |
| Nog/Rps18 | *<0.001 | *<0.001 | 0.795 | *0.003 | *0.019 | 0.588 | 0.232 |
| Pthlh/Rps18 | *<0.001 | 0.428 | 0.335 | *<0.001 | *<0.001 | 0.972 | 0.386 |
| Sox9/Rps18 | *0.002 | 0.352 | 0.818 | 0.654 | 0.707 | 0.787 | 0.151 |
| Tgfb1/Rps18 | 0.465 | 0.456 | 0.590 | *0.001 | 0.596 | 0.827 | 0.991 |
| Tgfb2/Rps18 | 0.968 | *0.001 | 0.328 | *<0.001 | 0.496 | 0.130 | 0.703 |
| Tgfb3/Rps18 | 0.141 | 0.393 | 0.814 | *0.045 | *<0.001 | 0.452 | 0.943 |
| Vegfa/Rps18 | *0.001 | 0.895 | 0.881 | *0.017 | 0.626 | 0.931 | 0.463 |
| Protein Secretion | |||||||
| FGF-2/DNA | 0.799 | 0.132 | *0.007 | 0.250 | 0.730 | 0.931 | *0.031 |
| IGF-I/DNA | *0.026 | *<0.001 | 0.184 | *<0.001 | 0.379 | *0.028 | *0.023 |
| TGF-β3/DNA | 0.965 | *<0.001 | *0.001 | *0.001 | 0.825 | 0.108 | 0.181 |
| VEGF-A/DNA | *<0.001 | *0.029 | 0.512 | 0.947 | 0.981 | 0.556 | 0.229 |
*p<0.05 CM vs GM for medium, μB vs.TCPS for μB, 1 week vs. 2 weeks for time, 1 passage vs. 3 passages for passage.