Fig. 1.
Transcriptional response to hypoxia in cytochrome c oxidase subunit 4 (COX4) paralogs in murine myoblast cells (Sol8) and human prostate cancer cells (LNCaP). Cells were exposed to 8 or 24 h of 2% O2; n = 6 per treatment. A: mRNA levels for COX4-1 and COX4-2, relative to control treatments. B: proportion of COX4 transcripts present as COX4-1 or COX4-2. C: relative mRNA levels for VEGFA, a known hypoxia-responsive gene. *Significant difference from the control treatment as determined by a Mann-Whitney U-test. Error bars depict SE.