Fig. 6.

Comparison of putative hypoxia-responsive elements (HREs) in the COX4-2 gene across vertebrates. A and B: human sequences for the 2 HREs and the oxygen-responsive element (ORE) were used to search for orthologous elements in other vertebrate species representing several different lineages. A: location of the 3 elements in relation to the 5′-untranslated region (5′-UTR) and the ATG start site (ATG) of COX4-2 is shown for major classes of vertebrates. B determined elements are presented in relation to the vertebrate phylogeny. Differences from the consensus (human) sequence are indicated by filled boxes containing the alternative nucleotide or deletion (represented by a dash).