Fig. 7.

Conservation of features in vertebrate COX4-2 peptides. A: alignment of human COX4-1 and COX4-2 amino acid sequences. The COX4 amino acids suggested to be involved in the ATP/ADP binding site are denoted by arrows (Arg-20, Arg-73, Tyr-75, Glu-77, and Trp-78), and the COX4-2 cysteines that may disrupt the site are denoted by asterisks (Cys-16 and Cys-30). B: conservation of COX4-2 adenylate-coordinating amino acids and cysteines across vertebrates. Species names and accession numbers for each polypeptide sequence used can be found in Table 1.