Table 1.

Hemodynamic assessments of control and SM22α-ET-1^−/− mice

	Normoxia		Chronic Hypoxia
	Control	SM22α-ET-1−/−	Control	SM22α-ET-1−/−
Hematocrit, %	44.2 ± 0.8 (6)	42.0 ± 2.1 (4)	54.2 ± 0.6† (3)	56.3 ± 3.2* (3)
Heart rate, beats/min	367 ± 31 (3)	373 ± 10.7 (4)	411 ± 16.7* (6)	419 ± 9.9* (4)
Body weight, g	28.8 ± 1.3 (12)	30.9 ± 1.2 (10)	25.3 ± 2.3* (5)	27.3 ± 2.3* (5)
Left ventricular fractional shortening, %	30.0 ± 3.7 (3)	30.0 ± 3.9 (4)	34.5 ± 0.7 (5)	30.8 ± 1.9 (4)
Aortic valve velocity time integral, cm	2.45 ± 0.3 (3)	2.84 ± 0.5 (4)	2.6 ± 0.3 (5)	2.35 ± 0.3 (4)

Values are expressed as means ± SE; numbers of mice per group are in parentheses.

^*P < 0.05,

^†P < 0.001, hypoxia vs. normoxia. ET-1, endothelin-1.