Fig. 7.
Deletion of Fn14 impairs liver progenitor expansion. A: representative immunohistochemistry of Fn14, LGR5, α-fetoprotein (αFP), pan-CK, and Sox9 in liver sections from WT mice fed ETOH diet and treated with CCl4 for 2 wk. Original magnification ×10. CV, central vein; PV, portal vein. B–D: morphometry data and mRNA expression for αFP (B) and Sox9 (C) and mRNA expression for keratin 7 (Krt7; D) for livers from WT and Fn14 KO mice. Results are expressed as fold change compared with control. Results were normalized to the housekeeping gene S9. All comparisons were calculated by 2-way ANOVA followed by Tukey's multiple-comparison post hoc test: **P < 0.01, ***P < 0.001.