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. 2014 Dec 10;308(4):F298–F308. doi: 10.1152/ajprenal.00459.2014

Fig. 7.

Fig. 7.

Protective effect of TIGAR inhibition on PFK-1 activity, ATP concentration, G6PD activity, NADPH level, lipid hydroperoxide level, and GSH level after severe IRI. siTIGAR or siControl (50 μg in 1 ml PBS) was injected within 10 s into mouse tail veins at 48 and 24 h before ischemia. Mice were subjected to 30 min of bilateral renal ischemia or sham operation followed by 6 or 24 h of reperfusion (n = 6). A: PFK-1 activity in kidneys. B: ATP concentration in kidneys. C: G6PD activity in kidneys. D: ratio of NADPH to NADPH + NADP+ in kidneys. E: lipid hydroperoxide level in kidneys. F: ratio of GSSG to GSSG + GSH in kidneys. Values are means ± SD. *P < 0.05 vs. sham; #P < 0.05 vs. siControl.