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Induction of fibroblast growth factor 21 (FGF21) by asparaginase requires GCN2. A: hepatic Fgf21 mRNA expression was determined by quantitative real-time PCR. B: FGF21 protein concentration in serum analyzed by enzyme-linked immunoassay. All mice were pair fed the same amount as the GA group. Values are means ± SE; n = 5–8 per group. Labeled means without a common letter differ (P < 0.05, drug × strain interaction effect).
