Table 2.

Hepatic plasma amino acid uptake

	Hypoglycemia
Uptake, μmol/min)	Basal	d1	d4	ANOVA†
Taurine	−0.18 ± 0.20	−0.17 ± 0.42	−0.38 ± 0.55	0.91
Aspartate	−0.27 ± 0.08	−0.26 ± 0.09	−0.13 ± 0.14	0.59
Threonine	1.27 ± 0.62	3.31 ± 0.73*	1.05 ± 0.42	<0.05
Serine	−4.92 ± 1.32	−2.42 ± 0.80	−6.81 ± 2.72	0.22
Asparagine	0.52 ± 0.31	1.38 ± 0.32	−1.00 ± 1.89	0.36
Glutamate	−10.03 ± 2.13	−5.52 ± 1.62*	−3.66 ± 1.21*	<0.01
Glutamine	6.41 ± 0.64	7.56 ± 1.26	5.97 ± 1.02	0.44
Proline	0.85 ± 0.28	1.65 ± 0.46	1.61 ± 0.55	0.26
Glycine	1.94 ± 0.67	3.99 ± 0.75*	3.73 ± 0.33*	<0.01
Alanine	3.68 ± 0.73	6.21 ± 1.13*	5.64 ± 1.13	0.08
Citruline	0.02 ± 0.16	0.09 ± 0.20	−0.13 ± 0.19	0.65
Valine	0.15 ± 0.63	1.03 ± 0.62	0.63 ± 0.34	0.53
Cysteine	−0.02 ± 0.04	0.10 ± 0.06	−0.27 ± 0.35	0.46
Methionine	1.29 ± 0.38	1.13 ± 0.29	1.17 ± 0.29	0.90
Isoleucine	0.45 ± 0.15	0.46 ± 0.20	0.35 ± 0.10	0.87
Leucine	0.98 ± 0.24	1.09 ± 0.25	0.77 ± 0.24	0.45
Tyrosine	1.73 ± 0.15	1.79 ± 0.26	1.73 ± 0.57	0.99
Phenylalanine	1.28 ± 0.21	1.60 ± 0.33	1.56 ± 0.49	0.40
Tryptophan	0.23 ± 0.08	0.47 ± 0.24	0.47 ± 0.41	0.62
Ornithine	−0.71 ± 0.19	−0.70 ± 0.30	−0.81 ± 0.35	0.90
Lysine	1.59 ± 0.36	2.49 ± 0.50*	1.96 ± 0.20	0.08
Histidine	0.74 ± 0.17	0.80 ± 0.19	0.72 ± 0.06	0.92
Arginine	2.87 ± 0.49	3.52 ± 0.60	3.23 ± 0.47	0.44
Glucogenic amino acid‡	19.71 ± 3.58	30.59 ± 5.09*	22.76 ± 4.54	0.09

Values are expressed as means ± SE. Measurements obtained during basal period and following d1 and d4 of hypoglycemia.

^*P < 0.05 vs. basal period.

^†Overall ANOVA P values are presented.

^‡Sum of theonine, asparigine, glutamine, proline, glycine, alanine, and valine.