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. 2015 Jan 20;5(4):322–344. doi: 10.7150/thno.10257

Figure 14.

Figure 14

Design of aptamer:siRNA conjugates. 27mer siRNAs (siRNA) were synthesized as either biotin conjugates (B-siRNA), or with a cleavable biotin linker (BSS-siRNA). Conjugates were assembled by incubation with streptavidin and on average each conjugate should have contained two siRNAs and two anti-PSMA aptamers. Reprinted with permission from ref. 131. Copyright (2006) Oxford University Press.