Table 2. Effects of three coccidiostats on the pharmacokinetics of florfenicol.

Parameter	Unit	FFC Alone	FFC + SUL	FFC + ROB	FFC + TOL
λz	1/h	0.46 ± 0.18	0.38 ± 0.14	0.61 ± 0.13*	0.36 ± 0.13
t1/2z	h	1.72 ± 0.67	2.09 ± 0.88	1.19 ± 0.29*	2.20 ± 0.88
AUC(0-t)	μg•h /ml	31.49 ± 6.40	27.72 ± 8.26	19.51 ± 4.30**	28.25 ± 6.47
AUC(0-∞)	μg•h /ml	32.34 ± 6.64	28.69 ± 8.00	19.85 ± 4.30**	28.89 ± 6.06
AUMC(0-∞)	μg•h2/ml	83.55 ± 43.51	79.44 ± 33.68	31.89 ± 14.01*	79.46 ± 22.87
MRT(0-∞)	h	2.49 ± 1.02	2.91 ± 1.48	1.57 ± 0.49*	2.88 ± 1.24
CLz	L/kg/h	0.81 ± 0.19	0.94 ± 0.28	1.31 ± 0.25**	0.91 ± 0.22
Vss	L/kg	1.92 ± 0.62	2.91 ± 2.25	2.00 ± 0.61	2.79 ± 2.08

Pharmacokinetics parameters of florfenicol (FFC) after a single intravenous injection (25 mg/kg) into rabbits which fed normal feed (anticoccidial-free) and the feed containing sulfaquinoxaline (SUL, 250 ppm), robenidine (ROB, 66 ppm), or toltrazuril (TOL, 2 ppm) for 20 days. Values are presented as the mean ± SD (n=8). λz, elimination rate constant; t1/2z, terminal elimination half-life; AUC, area under the plasma concentration–time curve; AUMC, area under the first moment curve; MRT, mean residence time; CLz, total body clearance; Vss, apparent steady-state volume of distribution; *P<0.05 and **P<0.01; significant difference from the FFC alone group.