Table 1. Participant-reported symptoms during double-blinded administration of vehicle and neurokinin B (Study 2). Ten healthy women were administered 30 min intravenous infusions of vehicle and neurokinin B (NKB, 5.12 nmol/kg/h) with a 90 min interval between infusions. Vehicle was administered first in participants 1,2,5,7 and 9, and NKB was administered first in participants 3,4,6,8 and 10. Participants were asked to verbally report any symptoms including their frequency and severity (0 no symptom, 1 mild heat sensation, 2 strong heat sensation and able to continue with general activity, 3 strong heat sensation unable to continue with current activity) to the study investigators in real-time during the study. Pre-study stress scores (1 low, 2 medium, 3 high) were recorded on arrival for the study.
| Participant Number | Pre-Study Stress Score (1–3) | Participant-reported symptoms | Maximum symptoms severity (0–3) | |
|---|---|---|---|---|
| 1st infusion | 2nd infusion | |||
| VEHICLE | NKB | |||
| 1 | 1 | None | Hot forehead, Hot ears, Headache, Warm | 2 |
| 2 | 1 | None | Hot face, Facial flushing, Headache, Warm | 3 |
| 5 | 2 | None | Hot face, ‘Hot air blowing on face’, Headache, Warm | 2 |
| 7 | 1 | None | None | 0 |
| 9 | 1 | None | Flushing, Clammy, ‘Face burning’, Warm face/arms | 2 |
| NKB | VEHICLE | |||
| 3 | 2 | Cheeks flushing, Warm | None | 2 |
| 4 | 1 | Warm face, Cold following warm | None | 2 |
| 8 | 1 | None | None | 0 |
| 6 | 1 | Hot head, Sweating, Head tingling, Clammy, Warm | None | 1 |
| 10 | 1 | Feels hot, Face sweating, Warm | None | 1 |