Table 3. PET Quantitative Analysis of Tumors and Selected Tissues at 1 and 3 h after i.v. Injection of Radiotracer in Mice.
compd | time | tumord | muscled | boned | TMRe |
---|---|---|---|---|---|
[18F]9a | 1 h | 6.8 ± 1.9 | 1.1 ± 0.6 | 0.9 ± 0.1 | 6.5 ± 2.4 |
3 h | 6.9 ± 0.5 | 0.4 ± 0.1 | 0.5 ± 0.1 | 15.5 ± 1.5 | |
[18F]FIB-NDP-MSHb | 1 h | 1.4 ± 0.9 | 0.3 ± 0.2 | 0.4 ± 0.2 | 4.0 ± 0.8 |
3 h | 0.7 ± 0.2 | 0.1 ± 0.0 | 0.2 ± 0.1 | 4.3 ± 1.2 | |
[18F]FIB-PRGD2c | 1 h | 7.3 ± 1.0 | 1.6 ± 0.7 | 1.7 ± 0.8 | 5.3 ± 2.5 |
3 h | 4.3 ± 1.0 | 0.9 ± 0.2 | 1.5 ± 0.9 | 4.9 ± 0.1 |
B16F0 primary melanoma-bearing C57BL/6J mice.
B16F10 primary melanoma-bearing C57BL/6J mice.
U87-MG primary glioblastoma-bearing nude mice.
Data are expressed as percentage of injected dose per gram of tissue (%ID·g–1) ± SD.
Tumor-to-muscle ratio.