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. 2015 Jan 8;6(2):134–139. doi: 10.1021/ml500348p

Figure 2.

Figure 2

Growth inhibition and induction of apoptosis by chloroquine (CQ), hydroxychloroquine (HCQ), and the indicated compounds. A–C: Human nonsmall cell lung cancer (NSCLC) and pancreatic cancer cells were treated for 72 h at the indicated concentrations and cell numbers quantified with SRB assays. Data are means ± SD of at least 3 experiments, each done in triplicate. D: H460 cells were treated with HCQ or EAD1 for 24 h. Drug-containing medium was replaced with drug-free medium, and colonies were stained with crystal violet after an additional 10 days. E: Apoptosis was determined in CQ, HCQ, and EAD1-treated H460 cells by incubation with APC-conjugated annexin V and flow cytometry. Values are means ± SD of 3 experiments. *Indicates significantly different from Control, CQ, and HCQ, p < 0.05.