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. 2015 Jan 8;6(2):134–139. doi: 10.1021/ml500348p

Scheme 2. Synthetic Route to Truncated Analogues.

Scheme 2

Reagents and conditions: (a) CuSO4, sodium ascorbate (53%); (b) propargylamine (6a) or N-methylpropargylamine (6b), Et3N, THF (52% for 6a; 49% for 6b); (c) CuSO4, sodium ascorbate (60% for 6a; 65% for 6b).