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. 2014 Dec 10;6(2):151–155. doi: 10.1021/ml500408d

Scheme 1. Synthesis of Ammonium, Pyridinium, and Quinolinium Salts.

Scheme 1

Reagents and conditions: (i) R3N (2.2 equiv for 1 and 2; 1.1 equiv for 3), CH3CN, 80 °C; (ii) pyridine or quinoline (2.2 equiv for 1 and 2; 1.1 equiv for 3), CH3CN, 80 °C; (iii) Bn2NH (1.1 equiv), K2CO3 (1.2 equiv), 60 °C then HClg/dioxane.