. 2014 Dec 10;6(2):151–155. doi: 10.1021/ml500408d

Table 1. In Vitro Antitrypanosomal Activity (EC₅₀, μM)^a against Wild Type and Resistant Strains of T. b. brucei and Cytotoxicity against HEK Cells (CC₅₀, μM).

graphic file with name ml-2014-00408d_0002.jpg

Mean of three experiments ± SEM.

T. b. brucei s427 trypomastigotes.

T. b. brucei knockout strain¹⁰ lacking a functional P2-transporter and resistant to diminazene aceturate.

Resistance factor compared to WT.

The B48 strain¹¹ is a mutant derived from the TbAT1-KO strain with a nonfunctional high affinity pentamidine transporter (HAPT). This strain is resistant to diminazene, pentamidine, and melaminophenyl arsenicals.

Human endothelial kidney cells.

Selectivity index = [CC₅₀/EC₅₀ (T.b.b.WT)].

Not determined.

Table 1. In Vitro Antitrypanosomal Activity (EC50, μM)a against Wild Type and Resistant Strains of T. b. brucei and Cytotoxicity against HEK Cells (CC50, μM).

Table 1. In Vitro Antitrypanosomal Activity (EC₅₀, μM)^a against Wild Type and Resistant Strains of T. b. brucei and Cytotoxicity against HEK Cells (CC₅₀, μM).