. 2014 Dec 27;6(2):162–167. doi: 10.1021/ml500459f

Table 1. Biological Activity of Isothiocyanate Analogues.

compd	IC₅₀ (μM)^a	% inhibition at 100 μM^b
11	148 ± 66.6	69
12	>200	26
15	>200	55
16	145 ± 105	61

Values determined employing the GFP-based LasR antagonist bioassay (see Supporting Information). All IC₅₀ values are reported as the mean of triplicate analysis with the range defining the 95% confidence interval. Br-HSL (4) was used as a control for antagonism with an IC₅₀ = 16.4 ± 7.4 μM.

Percent inhibition of GFP at 100 μM with respect to Br-HSL (4) as a positive control for LasR antagonism, set at 100% inhibition.