Table 3. Pharmacokinetic Properties of 15.
| iv |
po |
|||||
|---|---|---|---|---|---|---|
| species | dose iv/po (mg/kg) | CL (L/h/kg) | Vdss (L/kg) | T1/2 (h) | AUC (μM·h) | F (%) |
| rat | 2.0/2.0 | 0.68 | 1.8 | 4 | 3.49 | 50 |
| dog | 1.0/2.0 | 0.26 | 2.50 | 8.9 | 23.9 | 121 |
| cyno | 1.0/2.0 | 0.9 | 2.1 | 4.3 | 2.18 | 43 |
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