Table 2. Structure–Activity Relationship for CVB3 of Some Aimed Compounds.
| compd | R1 | R2 | TC50 (μM)a | IC50 (μM)b | SIc |
|---|---|---|---|---|---|
| 28a | m-CN | CO2CH3 | 288.0 | 11.7 | 24.6 |
| 28b | p-CF3 | CO2CH3 | 73.4 | 2.54 | 28.9 |
| 28c | o-NO2 | CO2CH3 | 398.8 | 23.9 | 16.7 |
| 28d | m-NO2 | CO2CH3 | 68.9 | 3.51 | 19.7 |
| 28e | m-CF3 | CO2CH3 | 193.3 | 1.98 | 92.4 |
| 29a | m-CN | COOH | 427.8 | 82.3 | 5.2 |
| 29b | p-CF3 | COOH | 391.7 | 75.4 | 5.2 |
| 29c | o-NO2 | COOH | 410.3 | 78.9 | 5.2 |
| 34a | m-CN | CH2OH | 147.0 | 11.3 | 13.0 |
| 34b | p-CF3 | CH2OH | 232.6 | 6.55 | 35.5 |
| 34c | o-NO2 | CH2OH | 243.9 | 35.7 | 6.8 |
| RBV | 8197 | 694.6 | 11.8 |
a
Cytotoxic concentration required to inhibit Vero cell growth by 50%.
b
Concentration required to inhibit CVB3 growth by 50%.
c
Selectivity index: TC50/IC50.