Table 1. LSD1, MAO-A, and MAO-B Enzyme Inhibiting Activity of the Pure Diastereomers 11a–d in Comparison with Their Mixture 11.

		IC50 (μM)b
compd	ACa	LSD1	MAO-A	MAO-B
11	mixture	0.15	0.32	40%c
11a	S,1R,2S	0.36	0.11	42.65
11b	S,1S,2R	0.03	0.14	32.02
11c	R,1R,2S	0.39	0.20	14%c
11d	R,1S,2R	0.05	0.22	33%c

^aAC, absolute configuration.

^bData represent mean values of at least two separate experiments in duplicate; the error is within ±10%.

^cPercentage of inhibition at 100 μM.