Scheme 3. Synthesis of Amine-Containing Lactams.
Reagents and conditions: (a) 6, NaH/K2CO3, DMF, 12 h, 20–30%; (b) 10% Pd/C, H2, AcOH, MeOH/EtOAc, rt, 2–3 d, 20–40%; (c) 40% TFA/DCM, DCM, rt, 4 h, 60%.
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