Table 1.
| a. Characteristics of children with invasive H. influenzae, 1999–2008 | ||||||
|---|---|---|---|---|---|---|
| Age <3 mos (n=216) % |
Age 3–11 mos (n=186) % |
Age 1–4 yrs (n=230) % |
Age 5–17 yrs (n=196) % |
Total (n=828) % |
||
| Serotypes | ||||||
| Nontypeable | 82.2 | 37.3 | 50.0 | 64.3 | 59.0 | |
| Non-b | 6.4 | 43.2 | 34.4 | 20.4 | 25.7 | |
| Type b | 3.2 | 11.9 | 7.4 | 5.1 | 6.7 | |
| Unknown | 8.2 | 7.6 | 8.3 | 10.2 | 8.6 | |
| Syndromes | ||||||
| Bacteremia w/o focus | 83.6 | 33.0 | 34.8 | 46.9 | 50.1 | |
| Pneumonia | 7.3 | 20.0 | 29.6 | 19.4 | 19.2 | |
| Meningitis | 5.9 | 33.5 | 19.1 | 14.3 | 17.7 | |
| Other | 3.2 | 13.5 | 16.5 | 19.4 | 13.0 | |
| Underlying conditions1 | ||||||
| Any condition | 51.2 | 10.6 | 23.2 | 35.3 | 27.3 | |
| Asthma | 0 | 3.9 | 11.4 | 12.6 | 6.2 | |
| Dialysis | 0 | 0 | 0.5 | 2.1 | 0.5 | |
| Heart failure | 0 | 0.6 | 1.4 | 0 | 0.4 | |
| Hematologic malig | 0 | 0 | 3.6 | 7.9 | 2.5 | |
| HIV/AIDS | 0 | 0.6 | 0 | 4.6 | 1.2 | |
| Immunocompromised | 0.5 | 2.2 | 10.0 | 14.2 | 6.0 | |
| Nephrotic syndrome | 0 | 0 | 0.5 | 2.6 | 0.7 | |
| Non-hematologic malig | 0 | 0 | 2.3 | 2.6 | 1.1 | |
| Prematurity | 49.8 | 2.8 | 1.4 | 0 | 12.7 | |
| Hospitalization | 94.1 | 80.5 | 78.3 | 74.0 | 81.9 | |
| Healthcare-associated HI | 4.6 | 6.5 | 8.7 | 6.6 | 6.6 | |
| Length of stay in days, median (IQR) | 11 (7–30) | 8 (4–14) | 6 (3–11) | 4 (3–9) | 8 (3–15) | |
| In-hospital Mortality | 16.2 | 6.5 | 4.4 | 5.6 | 8.3 | |
| b. Characteristics of adults with invasive H. influenzae, 1999–2008 | |||||
|---|---|---|---|---|---|
| Age 18–39 yrs (n=485) % |
Age 40–64 yrs (n=1341) % |
Age ≥ 65 yrs (n=2185) % |
Total (n=4011) % |
||
| Serotypes | |||||
| Nontypeable | 60.8 | 53.3 | 64.8 | 60.5 | |
| Non-b | 19.0 | 28.2 | 20.3 | 22.8 | |
| Type b | 2.3 | 3.4 | 1.7 | 2.3 | |
| Unknown | 17.9 | 15.2 | 13.1 | 14.4 | |
| Syndromes | |||||
| Bacteremia w/o focus | 37.7 | 32.1 | 26.5 | 29.7 | |
| Pneumonia | 31.3 | 51.2 | 66.2 | 56.9 | |
| Meningitis | 9.7 | 6.9 | 2.8 | 5.0 | |
| Other | 21.2 | 9.9 | 4.6 | 8.4 | |
| Underlying conditions2 | |||||
| Any condition | 51.3 | 75.2 | 79.6 | 74.8 | |
| Alcohol | 5.9 | 12.5 | 2.8 | 6.4 | |
| Asthma | 9.0 | 10.7 | 6.0 | 7.9 | |
| ASCVD | 0.4 | 9.1 | 28.7 | 18.8 | |
| Cirrhosis | 2.0 | 4.7 | 1.3 | 2.5 | |
| COPD | 2.2 | 16.4 | 29.6 | 21.9 | |
| CSF leak | 0.9 | 0.6 | 0.1 | 0.4 | |
| CVA3 | 0.3 | 3.0 | 7.7 | 4.6 | |
| Diabetes | 6.1 | 19.2 | 22.4 | 19.4 | |
| Dialysis | 4.4 | 7.3 | 7.9 | 7.3 | |
| Heart failure | 1.5 | 7.5 | 25.7 | 16.8 | |
| Hematologic malig | 2.2 | 7.2 | 6.8 | 6.4 | |
| HIV/AIDS | 13.3 | 7.7 | 0.1 | 4.2 | |
| Immunocompromised | 9.0 | 14.9 | 11.3 | 12.2 | |
| IVDU | 4.6 | 3.7 | 0 | 1.8 | |
| Lupus | 1.8 | 0.8 | 0.4 | 0.7 | |
| Nephrotic syndrome | 0.4 | 0.3 | 1.2 | 0.8 | |
| Non-hematologic malig | 2.6 | 10.0 | 12.3 | 10.4 | |
| Smoker3 | 21.9 | 27.9 | 8.3 | 16.5 | |
| Hospitalization | 85.6 | 91.0 | 94.9 | 92.5 | |
| Healthcare-associated HI | 7.8 | 7.5 | 5.2 | 6.3 | |
| Length of stay in days, median (IQR) | 4 (3–9) | 7 (4–13) | 6 (4–11) | 6 (4–11) | |
| In-hospital Mortality | 7.1 | 12.4 | 21.9 | 17.0 | |
1
Information on underlying conditions was available for 215 cases <3 mos, 180 cases 3–11 mos, 220 cases 1–4 yrs, and 190 cases 5–17 yrs. HIV status was not collected in New York State.
2
Information on underlying conditions was available for 456 cases 18–39 yrs, 1276 cases 40–64 yrs, and 2106 cases ≥65 yrs. HIV status was not recorded in New York State.
3
Surveillance for smoking status began in 2000 and for CVA in 2001.