Table 6. Properties of the helices of the C-terminal domain of the Zaire Ebola virus nucleoprotein (PDBid:4QAZA).
4QAZA.HELIX0 comprising of residues 646-658 has a reasonably large hydrophobic moment, and has been hypothesized to be part of the protein which is involved in protein-protein interactions 41. Further, these helices have residues with disordered sidechains 41, which are known to be critical for moonlighting functions 39. HM: Hydrophobic moment, RPNR: Ratio of the positive to the negative residues, Len: length of the helix, NCH: number of charged residues.
| Helix | Len | HM | RPNR | NCH |
|---|---|---|---|---|
| 4QAZA.HELIX0
4QAZA.HELIX1 4QAZA.HELIX2 4QAZA.HELIX3 4QAZA.HELIX4 4QAZA.HELIX5 4QAZA.HELIX6 |
13
12 3 3 4 3 11 |
8.4
0.8 2.5 2.4 1.8 0.1 2.1 |
0.7
0.7 0 0 0.3 -1 1 |
6
3 1 1 3 0 4 |