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. 2014 Nov 18;3:282. [Version 1] doi: 10.12688/f1000research.5654.1

Table 1. Splicing regulatory protein binding sites ASSEDA scans for and their associated effect on : splicing.

Splicing Factor R sequence (bits) Sequence Logo Location-dependent effect on splicing
Intronic Exonic
hnRNPH1 8.9 ± 1.8 graphic file with name f1000research-3-6038-g0005.jpg E 79, 80 / S 81, 82 S / E 83
hnRNPA1 i 4.6 ± 1.5 graphic file with name f1000research-3-6038-g0006.jpg S / E 84 S
TIA1 7.6 ± 3.1 graphic file with name f1000research-3-6038-g0007.jpg E N/A
SRSF6 (SRp55) 5.2 ± 1.4 graphic file with name f1000research-3-6038-g0008.jpg E / S 82 E / S
SRSF5 (SRp40) 4.5 ± 1.5 graphic file with name f1000research-3-6038-g0009.jpg E / S 82 E / S 85
SRSF2 (SC35) 4.5 ± 1.6 graphic file with name f1000research-3-6038-g0010.jpg E / S 86 E / S 87
SRSF1 (SF2/ASF) 88 5.8 ± 1.5 graphic file with name f1000research-3-6038-g0011.jpg E / S 86, 89, 90 E / S
PTB ii 4.9 ± 1.9 graphic file with name f1000research-3-6038-g0012.jpg S / E 91 S
ELAV1 9.6 ± 3.4 graphic file with name f1000research-3-6038-g0013.jpg S / E / N 92, 93 S

Reported dominant effect is bolded. E – Enhancer; S – Silencer; N - Neutral.

iEnhancer activity by hnRNP A1 occurs at the junction 84. iiPTB does not directly enhance splicing, but can do so indirectly by preventing the binding of splicing repressors 91.