Skip to main content
. Author manuscript; available in PMC: 2015 Feb 16.
Published in final edited form as: Transpl Int. 2007 Mar 16;20(6):534–541. doi: 10.1111/j.1432-2277.2007.00470.x

Figure 4.

Figure 4

Absence of class II self-MHC molecules similarly compromises the expansion and/or survival of TRegs and CD4+CD25− T cells. 1 × 106 CD45.1+ TRegs or CD45.1+ CD4+CD25− T cells were transferred into CD45.2+ Rag−/− syngeneic recipients bearing DBA/2 skin allografts, and 14 days later the number of CD4+ CD45.1+ cells recovered from either spleen or draining lymph nodes was quantified by flow cytometry. In Rag−/− recipients genetically lacking MHC-II, the expansion of both TRegs and CD4+CD25− T cells was similarly decreased. The results shown here correspond to 1 experiment representative of 3.