Table 3.

WOMAC subset and total scores.

	Median score		Median change	Median  % change
	Baseline	Week 12
WOMAC-A
Diclofenac	29.0	15.0	−13.5*	−48.1*
	(28.0, 31.0)	(13.0, 17.0)	(−16.0, −11.0)	(−55.2, −40.0)
Wobenzym	31.0	19.0	−12.5*	−39.7*
	(30.0, 31.0)	(17.0, 23.0)	(−15.0, −10.0)	(−47.1, −28.0)
Placebo	30.0	21.0	−8.0*	−28.1*
	(28.0, 31.0)	(17.0, 25.0)	(−13.0, −5.0)	(−44.8, −16.7)
WOMAC-B
Diclofenac	12.0	6.0	−4.0*	−43.7*
	(11.0, 13.0)	(5.0, 7.0)	(−6.0, −3.0)	(−57.1, −21.4)
Wobenzym	11.0	8.0	−4.0*	−33.3*
	(10.0, 12.0)	(6.0, 8.0)	(−4.0, −3.0)	(−41.7, −27.3)
Placebo	12.0	8.0	−3.0*	−26.2*
	(10.0, 13.0)	(6.0, 10.0)	(−4.0, −2.0)	(−35.7, −16.7)
WOMAC-C
Diclofenac	100.0	53.0	−32.0*	−36.2∗A
	(93.0, 106.0)	(45.0, 64.0)	(−47.0, −20.0)	(−54.7, −24.0)
Wobenzym	101.5	70.0	−28.5*	−30.3∗AB
	(96.0, 108.0)	(65.0, 82.0)	(−37.0, −20.0)	(−39.4, −21.1)
Placebo	102.0	75.0	−19.0*	−19.7∗B
	(92.0, 107.0)	(66.0, 88.0)	(−27.0, −14.0)	(−34.3, −12.7)
WOMAC total
Diclofenac	136.5	74.0	−50.0*	−38.3∗A
	(133.0, 146.0)	(62.0, 86.0)	(−73.0, −25.0)	(−54.4, −28.8)
Wobenzym	142.5	96.0	−46.5*	−35.5∗AB
	(136.0, 153.0)	(88.0, 114.0)	(−57.0, −34.0)	(−39.4, −21.1)
Placebo	144.5	101.5	−26.5*	−17.3∗B
	(129.0, 151.0)	(92.0, 123.0)	(−51.0, −22.0)	(−36.6, −12.5)

All values presented as medians (95% confidence interval).

^*Significantly different from “no change” (P < 0.05).

^A,BTreatment groups with different superscripts differ within the same column (P < 0.05).