Table 1.
Dilated cardiomyopathy n=60 |
Control subjects n=30 |
P-value | |
---|---|---|---|
Age, years, Med (range) | 57 (23–74) | 59 (28–73) | 0·59 |
Male, (%) | 48 (80) | 17 (57) | 0·02 |
BMI, kg/m2, Med | 27·7 (24·9–30·8) | 26·2 (24·1–29·1) | 0·21 |
LVEF, %, Med (range) | 32 (13–50) | 67 (54–79) | <0·001 |
LVEF = 40–50% | 11 (18) | 0 | |
LVEF = 31–39% | 25 (42) | 0 | |
LVEF = 25–30% | 16 (27) | 0 | |
LVEF = < 25% | 8 (13) | 0 | |
NYHA classification | 0·043 | ||
NYHA I | 25 (42) | 15 (50) | |
NYHA II | 24 (40) | 15 (50) | |
NYHA III | 11 (18) | 0 | |
Left bundle branch block (>120msec) | 27 (45) | 0 | <0·001 |
Hypertension | 52 (87) | 23 (77) | 0·23 |
Diabtes mellitus | 14 (23) | 2 (7) | 0·051 |
Renal dysfunction | 17 (28) | 0 | 0·001 |
Stroke | 6 (10) | 1 (3) | 0·27 |
Syncope | 8 (13) | 1 (3) | 0·14 |
Non-sustained VT | 12 (24) | 1 (3) | 0·84 |
Medication | |||
Beta-blocker | 54 (90) | 18 (60) | <0·001 |
Sotalol | 1 (2) | 2 (7) | 0·21 |
Amiodarone | 10 (17) | 0 | 0·018 |
ACE inhibitors | 51 (85) | 11 (37) | <0·001 |
Angiotensin receptor blockers | 22 (37) | 8 (27) | 0·34 |
Diuretics | 38 (63) | 7 (23) | <0·001 |
Follow-up, years, Med (mean±SD) | 1·8 6·6 6·8 (4·8±2·6) | 8·7 8·7 8·7 (8·5±1) | <0·001 |
ICD implanted | 10 (17) | 0 | 0·018 |
CRT-P / -D implanted | 7 (12) / 4 (7)* | 0 | <0·001 |
ICD therapy | 7 (12) | 0 | 0·036 |
Data are n (%), unless otherwise indicated; Med=median (Q1–Q3); test used: Wilxocon test or chi-square test. Renal dysfunction= persistent serum creatinine >1.2mg/dl.
4 CRT-D upgrades during follow-up