Table 2. Genes that decreased early in the time course then increased.

Gene list from cluster 3 showing genes that exhibit the early down-late up trend. The 1.5hr timepoint is highlighted in green to show the fold decrease of each gene early the time course. The fold change cut off is −1.2. A majority of the genes within this cluster also reflect a decrease in expression at the 3hr time point before plateauing to baseline by 6–12hrs. The p-value associated with each gene is based on reproducible replicate measurements and reflects a significant change (p≤ 0.05) in probe intensity for one or more timepoints relative to the untreated control.

CLUSTER 3: EARLY DOWN-LATE UP				FOLD CHANGE RELATIVE TO CONTROL
Affymetrix ID	p-value	Gene Symbol	Gene Name	1.5hrs	3hrs	6hrs	12hrs
10902409	0.0161	LOC688019	similar to THAP domain containing, apoptosis associated protein 2	−1.82	−1.65	−1.13	1.17
10912412	0.0081	Tfdp2	transcription factor Dp-2 (E2F dimerization partner 2)	−1.71	−1.55	−1.04	−1.07
10705431	0.0175	LOC499110	similar to Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1)	−1.62	−1.44	−1.18	1.20
10876567	0.0164	Xpa | Ncbp1	xeroderma pigmentosum, complementation group A | nuclear cap binding protein subunit 1	−1.55	−1.56	−1.17	1.01
10760760	0.0469	LOC288521	similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen)	−1.53	−1.41	−1.34	1.79
10849813	0.0495	Zc3h8	zinc finger CCCH type containing 8	−1.53	−1.48	−1.19	1.06
10717779	0.0307	Fbxo5	F-box protein 5	−1.51	−1.38	−1.21	1.37
10752007	0.0191	Dgkg	diacylglycerol kinase, gamma	−1.49	−1.52	−1.13	1.00
10833668	0.0368	Gpbp1l1	GC-rich promoter binding protein 1-like 1	−1.49	−1.45	−1.12	1.14
10836633	0.0195	Phospho2	phosphatase, orphan 2	−1.48	−1.36	−1.19	1.18
10804371	0.0328	Ccdc112	coiled-coil domain containing 112	−1.47	−1.28	−1.15	−1.17
10917087	0.0105	Fam55b	family with sequence similarity 55, member B	−1.47	−1.58	−1.18	−1.04
10871250	0.0361	Gpbp1l1	GC-rich promoter binding protein 1-like 1	−1.47	−1.42	−1.10	1.16
10819130	0.0343	Gpbp1l1	GC-rich promoter binding protein 1-like 1	−1.47	−1.45	−1.09	1.15
10908990	0.0348	Pus3	pseudouridylate synthase 3	−1.47	−1.27	−1.16	1.02
10798376	0.0279	Ttrap	Traf and Tnf receptor associated protein	−1.46	−1.30	−1.19	−1.00
10811216	0.0380	Adat1	adenosine deaminase, tRNA-specific 1	−1.46	−1.37	−1.13	1.09
10774435	0.0449	Gpbp1l1	GC-rich promoter binding protein 1-like 1	−1.46	−1.45	−1.09	1.14
10822961	0.0378	Mfsd8	major facilitator superfamily domain containing 8	−1.46	−1.51	−1.18	1.10
10867688	0.0444	Rbml2b	RNA binding motif protein 12B	−1.46	−1.53	−1.03	1.01
10876896	0.0180	Ctnnal1	catenin (cadherin associated protein), alpha-like 1	−1.45	−1.34	−1.10	−1.22
10750812	0.0433	Cep97	centrosomal protein 97kDa	−1.45	−1.39	−1.10	−1.08
10931638	0.0251	Cbx8	chromobox homolog 8 (Pc class homolog, Drosophila)	−1.45	−1.10	−1.11	−1.15
10719829	0.0214	Lipe	lipase, hormone sensitive	−1.45	−1.17	−1.08	1.16
10885931	0.0269	RGD1560978	similar to hypothetical protein	−1.44	−1.39	−1.17	−1.07
10742104	0.0464	Gpbp1l1	GC-rich promoter binding protein 1-like 1	−1.44	−1.44	−1.08	1.15
10759241	0.0217	Hscb	HscB iron-sulfur cluster co-chaperone homolog (E. coli)	−1.43	−1.23	−1.11	1.00
10704752	0.0300	Fbxo46	F-box protein 46	−1.43	−1.16	−1.18	1.05
10826158	0.0494	Prmt6	protein arginine methyltransferase 6	−1.42	−1.33	−1.15	1.16
10811208	0.0033	Tmem231	transmembrane protein 231	−1.41	−1.37	−1.15	1.08
10705772	0.0063	Zfp84	zinc finger protein 84	−1.41	−1.39	−1.19	1.08
10704234	0.0417	Zfp128	zinc finger protein 128	−1.39	−1.20	−1.19	1.19
10846173	0.0489	Cir1	corepressor interacting with RBPJ, 1	−1.39	−1.27	−1.13	1.11
10731787	0.0467	Tcfap4	transcription factor AP4	−1.38	−1.29	−1.08	−1.04
10918374	0.0460	Rab8b	RAB8B, member RAS oncogene family	−1.38	−1.35	−1.06	1.07
10885464	0.0160	Fut8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	−1.38	−1.42	−1.01	1.07
10807464	0.0057	Pla2g15	phospholipase A2, group XV	−1.37	−1.18	−1.06	1.02
10794099	0.0040	Uimc1	ubiquitin interaction motif containing 1	−1.37	−1.27	−1.09	−1.07
10704918	0.0285	RGD1564214	similar to Zfp93 protein	−1.37	−1.20	−1.14	1.08
10778579	0.0116	Etaa1	Ewing tumor-associated antigen 1	−1.37	−1.29	−1.09	1.04
10883606	0.0338	Rdh14	retinol dehydrogenase 14 (all-trans/9-cis/11-cis)	−1.37	−1.27	−1.10	−1.05
10829703	0.0436	Tfam	transcription factor A, mitochondrial	−1.37	−1.26	−1.15	1.02
10905148	0.0136	Znf250	zinc finger protein 250	−1.36	−1.12	−1.12	1.16
10891818	0.0331	Atxn3	ataxin 3	−1.36	−1.30	−1.13	−1.13
10708235	0.0008	Zfp29	zinc finger protein 29	−1.36	−1.26	−1.14	1.15
10757140	0.0417	Zfp68	zinc finger protein 68	−1.35	−1.43	−1.15	1.08
10807504	0.0022	Zfp90	zinc finger protein 90	−1.35	−1.34	−1.10	1.03
10933494	0.0060	LOC302680	similar to CXORF15	−1.35	−1.32	−1.15	1.06
10832460	0.0156	Zfp280b	zinc finger protein 280b	−1.35	−1.15	−1.09	1.35
10908248	0.0174	Zfp42612	zinc finger protein 426-like 2	−1.35	−1.26	−1.07	−1.12
10803953	0.0006	Sra1	steroid receptor RNA activator 1	−1.35	−1.05	−1.19	−1.17
10894221	0.0262	Zfp472	zinc finger protein 472	−1.34	−1.22	−1.11	−1.00
10743608	0.0131	Znf286a	zinc finger protein 286A	−1.33	−1.18	−1.09	1.10
10782695	0.0158	Abhd6	abhydrolase domain containing 6	−1.33	−1.35	−1.07	1.21
10865630	0.0433	Ncapd2	non-SMC condensin 1 complex, subunit D2	−1.32	−1.25	−1.11	1.05
10864979	0.0389	Ankrd26	ankyrin repeat domain 26	−1.32	−1.32	1.00	1.04
10924199	0.0148	Smarcal1	Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	−1.32	−1.19	−1.02	1.14
10878912	0.0240	Toe1	target of EGR1, member 1 (nuclear)	−1.32	−1.12	1.01	1.34
10860226	0.0281	Lrrcl7 | Fbxl13	leucine rich repeat containing 17 | F-box and leucine-rich repeat protein 13	−1.31	1.05	−1.13	−1.02
10733726	0.0081	Mfap3	microfibrillar-associtaed protein 3	−1.31	−1.36	−1.09	1.10
10742431	0.0217	Rufy1	RUN and FYVE domain containing 1	−1.31	−1.12	−1.09	−1.12
10726655	0.0300	Bet1l	blocked early in transport 1 homolog (S. cerevisiae) like	−1.31	−1.10	−1.14	−1.08
10739099	0.0106	Map3k3	mitogen activated protein kinase kinase kinase 3	−1.31	−1,16	−1.14	−1.02
10826764	0.0237	Rrh	retinal pigment epithelium derived rhodopsin homolog	−1.31	−1.34	−1.08	1.18
10758094	0.0067	Slc15a4	solute carrier family 15, member 4	−1.30	−1.35	−1.19	−1.00
10779668	0.0092	Socs4	suppressor of cytokine signaling 4	−1.30	1.01	−1.13	−1.07
10883321	0.0361	Asxl2	additional sex combs like 2 (Drosophila)	−1.30	−1.19	−1.20	1.04
10889660	0.0385	Ahr	aryl hydrocarbon receptor	−1.30	−1.47	−1.08	−1.04
10904242	0.0163	RGD1308133	similar to RIKEN cDNA 1700010C24	−1.30	−1.16	−1.02	1.01
10830989	0.0322	Ppp1r10	protein phosphatase 1, regulatory subunit 10	−1.29	−1.19	−1.09	1.36
10891364	0.0239	Alkbh	alkB, alkylation repair homolog (E. coli)	−1.29	−1.21	−1.08	1.23
10838197	0.0239	Cstf3	cleavage stimulation factor, 3’ pre-RNA, subunit 3	−1.29	−1.29	−1.19	1.03
10736509	0.0413	Gosr1	golgi SNAP receptor complex member 1	−1 79	−1 18	−1.07	1.07
10800603	0.0245	Pik3c3	phosphoinositide-3-kinase, class 3	−1.29	−1.19	−1.09	1.03
10924392	0.0147	Ttll4	tubulin tyrosine ligase-like family, member 4	−1.29	−1.34	−1.14	1.08
10753231	0.0498	Setd4	SET domain containing 4	−1.29	−1.24	−1.07	1.04
10852034	0.0350	Zfp64 | Zfp93	zinc finger protein 64 | zinc finger protein 93	−1.29	−1.15	−1.12	−1.01
10751362	0.0365	Stxbp5l	syntaxin binding protein 5-like	−1.29	−1.40	−1.08	1.04
10807430	0.0191	Pskh1	protein serine kinase H1	−1.28	−1.10	−1.03	1.07
10801209	0.0459	Pcdhb21	protocadherin beta 21	−1.28	−1.26	−1.07	1.08
10891271	0.0481	Nek9	NIMA (never in mitosis gene a)- related kinase 9	−1.28	−1.12	−1.01	1.04
10904233	0.0163	RGD1308133	similar to RIKEN cDNA 1700010C24	−1.28	−1.20	1.08	1.16
10799893	0.0396	LOC686314	similar to dachshund b	−1.28	−1.28	−1.15	1.14
10910222	0.0449	Hmg20a	high mobility group 20A	−1.28	−1.25	−1.12	1.03
10782689	0.0114	Rpp14	ribonuclease P 14 subunit (human)	−1.28	−1.28	−1.28	1.02
10817396	0.0288	Arnt	aryl hydrocarbon receptor nuclear translocator	−1.27	−1.23	−1.04	1.08
10768874	0.0441	Cep350	centrosomal protein 350kDa	−1.27	−1.25	−1.19	−1.17
10876717	0.0410	Mrpl50	mitochondrial ribosomal protein L50	−1.27	−1.20	−1.02	−1.19
10706619	0.0465	Vrk3	vaccinia related kinases 3	−1.27	−1.18	−1.05	1.09
10757555	0.0049	Prkrip1	Prkr interacting protein 1 (IL11 inducible)	−1.27	−1.07	−1.02	1.11
10905362	0.0318	Ankrd54	ankyrin repeat domain 54	−1.27	−1.23	−1.19	1.09
10704902	0.0026	Zfp112	zinc finger protein 112	−1.27	−1.34	−1.15	1.13
10789470	0.0310	Dcun1d2	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	−1.27	−1.35	−1.17	1.10
10876169	0.0351	RGD1306576	similar to hypothetical protein	−1.27	−1.06	−1.13	1.08
10711127	0.0409	Phkg2	phosphorylase kinase, gamma 2 (testis)	−1.26	−1.11	−1.12	1.15
10737389	0.0178	Tubd1 | LOC100363	tubulin, delta 1 | tubulin, delta 1-like	−1.26	−1.19	−1.05	−1.01
10833806	0.0358	Armc2	armadillo repeat containing 2	−1.26	−1.25	−1.09	1.13
10862376	0.0157	Zfp786	zinc finger protein 786	−1.26	−1.25	−1.05	−1.00
10912959	0.0398	Tusc4	tumor suppressor candidate 4	−1.26	−1.12	−1.10	1.10
10743600	0.0353	Znf287	zinc finger protein 287	−1.26	−1.33	−1.09	1.23
10742236	0.0151	Thg1l	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)	−1.26	−1.15	−1.11	1.04
10757239	0.0327	Cnpy4	canopy 4 homolog (zebrafish)	−1.26	−1.12	−1.06	1.10
10875425	0.0370	RGD1309085	similar to F23N19.9	−1.25	−1.21	−1.14	1.03
10907268	0.0129	Tcfcp2	transcription factor CP2	−1.25	−1.05	−1.05	−1.02
10767175	0.0068	Insig2	insulin induced gene 2	−1.25	−1.26	−1.18	−1.17
10725286	0.0251	Gpr139	G protein-coupled receptor 139	−1.25	−1.40	1.04	1.26
10908827	0.0359	Prdm10	PR domain containing 10	−1.25	−1.62	−1.04	1.02
10914940	0.0478	Kdm4d	lysine (K)-specific demethylase 4D	−1.25	−1.20	−1.14	1.25
10912099	0.0374	RGD1561074|LOC	similar to tripartite motif-containing 43 | hypothetical protein LOC100233177	−1.25	−1.26	−1.15	−1.02
10812438	0.0139	Acot12	acyl-CoA thioesterase 12	−1.25	−1.35	−1.24	1.18
10875771	0.0030	Klhl32	kelch-like 32 (Drosophila)	−1.25	−1.31	−1.08	1.15
10710028	0.0445	Arntl	aryl hydrocarbon receptor nuclear translocator-like	−1.25	−1.08	−1.0S	1.14
10836570	0.0462	Nostrin	nitric oxide synthase trafficker	−1.25	−1.14	−1.12	1.24
10824300	0.0354	Slc25a44	solute carrier family 25, member 44	−1.25	−1.15	−1.19	1.01
10839423	0.0416	Galk2	galactokinase 2	−1.25	−1.18	−1.01	1.13
10772107	0.0407	Cenpc1	centromere protein C 1	−1.24	−1.36	−1.10	1.11
10891445	0.0248	Ston2	stonin 2	−1.24	−1.24	−1.04	−1.11
10754506	0.0402	Ptplb	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	−1.24	−1.21	−1.06	1.01
10840038	0.0033	RGD1561852	similar to Protein C20orf29	−1.24	−1.14	−1.03	1.01
10767102	0.0336	Epb4.1l5	erythrocyte protein band 4.1-like 5	−1.24	−1.14	−1.01	−1.04
10870929	0.0393	Ttc39a	tetratricopeptide repeat domain 39A	−1.24	−1.22	−1.22	1.25
10843634	0.0416	Ubac1	UBA domain containing 1	−1.24	−1.17	−1.15	−1.09
10863187	0.0343	Rnf181	ring finger protein 181	−1.24	−1.03	−1.06	1.12
10774825	0.0332	RGD1562229	similar to hypothetical protein FLJ40298	−1.24	−1.22	−1.18	−1.00
10885951	0.0316	Vsx2	visual system homeobox 2	−1.24	−1.20	−1.15	−1.00
10839803	0.0184	Rpl22l1 | Rpl22l2	ribosomal protein L22 like 1 | ribosomal protein L22-like 2	−1.24	−1.22	−1.20	−1.00
10797344	0.0013	Zfp346	zinc finger protein 346	−1.24	−1.12	−1.05	1.04
10901563	0.0170	Chpt1	choline phosphotransferase 1	−1.24	−1.09	1.03	1.05
10921141	0.0281	Fyco1	FYVE and coiled-coil domain containing 1	−1.23	−1.21	−1.11	1.05
10833013	0.0172	Unc5b	unc-5 homolog B (C. elegans)	−1.23	−1.15	−1.00	−1.19
10845322	0.0015	Stam2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	−1.23	−1.02	−1.18	−1.20
10806698	0.0334	Mri1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)	−1.23	−1.05	−1.00	1.26
10901253	0.0109	Pwp1	PWP1 homolog (S. cerevisiae)	−1.23	−1.10	1.04	−1.06
10786422	0.0036	Actr8	ARP8 actin-related protein 8 homolog (yeast)	−1.23	−1.17	−1.11	1.03
10806709	0.0052	Zswim4	zinc finger, SWIM-type containing 4	−1.23	−1.13	−1.09	−1.10
10809856	0.0016	Orc6l	origin recognition complex, subunit 6 like (yeast)	−1.23	−1.19	−1.03	1.05
10786204	0.0004	Fam116a	family with sequence similarity 116, member A	−1.23	−1.19	−1.00	−1.01
10731385	0.0090	Parn	poly(A)-specific ribonuclease (deadenylation nuclease)	−1.23	−1.13	−1.02	−1.00
10770566	0.0379	Rpl7a | RGD156295	ribosomal protein L7a | similar to Rpl7a protein | similar to 60S ribosomal protein L7a	−1.23	−1.11	−1.07	−1.04
10701717	0.0021	Katna1	katanin p60 (ATPase-containing) subunit A1	−1.23	−1.09	−1.02	1.01
10916016	0.0394	St3gal4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	−1.23	−1.09	−1.09	−1.03
10748361	0.0445	Smurf2	SMAD specific E3 ubiquitin protein ligase 2	−1.23	−1.17	−1.15	−1.15
10891026	0.0283	Zfyve1	zinc finger, FYVE domain containing 1	−1.23	−1.11	−1.04	1.05
10908960	0.0285	Rpusd4	RNA pseudouridylate synthase domain containing 4	−1.22	−1.07	−1.03	−1.03
10927233	0.0318	Zfp451	zinc finger protein 451	−1.22	−1.10	−1.06	1.00
10846340	0.0346	Fkbp7	FK506 binding protein 7	−1.22	−1.21	1.05	−1.05
10777337	0.0094	Stx18	syntaxin 18	−1.22	1.04	−1.15	−1.12
10814398	0.0441	Mtfr1	mitochondrial fission regulator 1	−1.22	−1.27	−1.09	−1.37
10859864	0.0493	Rbm33	RNA binding motif protein 33	−1.22	−1.19	−1.07	−1.00
10730287	0.0175	RGD1307934	similar to DNA segment, Chr 19, ERATO Doi 386, expressed	−1.22	−1.13	−1.03	1.33
10911016	0.0056	Csnk1g1	casein kinase 1, gamma 1	−1.22	−1.19	−1.04	−1.04
10892381	0.0348	Nudt14	nudix (nucleoside diphosphate linked moiety X)-type motif 14	−1.22	1.18	−1.28	−1.23
10910966	0.0165	Mtfmt	mitochondrial methionyl-tRNA formyltransferase	−1.22	−1.08	−1.02	1.20
10710627	0.0369	Plk1	polo-like kinase 1 (Drosophila)	−1.22	−1.22	−1.08	1.11
10736000	0.0302	Myo1c	myosin IC	−1.22	−1.03	1.03	−1.07
10805029	0.0183	Ptpn2	protein tyrosine phosphatase, non-receptor type 2	−1.21	−1.17	−1.09	1.05
10891436	0.0393	Gtf2a1	general transcription factor IIA, 1	−1.21	−1.12	−1.02	−1.17
10905465	0.0306	Unc84b	unc-84 homolog B (C.elegans)	−1.21	−1.19	−1.04	−1.03
10750373	0.0160	Morc3	MORC family CW-type zinc finger 3	−1.21	−1.20	−1.10	−1.06
10886322	0.0123	Ttc8	tetratricopeptide repeat domain 8	−1.21	−1.12	1.00	1.02
10859264	0.0093	Ddx47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	−1.21	1.05	−1.17	−1.04
10720539	0.0133	LOC499124	mouse zinc finger protein 14-like	−1.21	−1.21	−1.03	1.04
10787117	0.0126	Med26	mediator complex subunit 26	−1.21	−1.10	−1.14	1.22
10865077	0.0172	Lrtm2	leucine-rich repeats and transmembrane domains 2	−1.21	−1.13	−1.00	−1.16
10905270	0.0494	Rabl4	RAB, member of RAS oncogene family-like 4	−1.21	−1.18	1.01	1.01
10771119	0.0115	Znf644	zinc finger protein 644	−1.21	−1.14	−1.05	1.06
10710806	0.0082	LOC361646	similar to K04F10.2	−1.21	−1.09	−1.12	−1.17
10850793	0.0074	Zcchc3	zinc finger, CCHC domain containing 3	−1.21	−1.13	−1.07	1.07
10796455	0.0226	Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	−1.20	−1.14	−1.10	−1.12
10748021	0.0158	Map3k14	mitogen-activated protein kinase kinase kinase 14	−1.20	−1.03	−1.03	1.03
10729715	0.0146	Sgms1	sphingomyelin synthase 1	−1.20	−1.19	−1.01	1.09
10727867	0.0343	Mus81	MUS81 endonuclease homolog (S. cereuisiae)	−1.20	1.01	1.01	−1.00
10800173	0.0282	Rbbp8	retinoblastoma binding protein 8	−1.20	−1.16	−1.03	1.05