Table 3. Functional classification of genes in cluster 2: early up, late down.
Functional classification of genes in cluster 2 (Table 1). The table highlights gene enrichment for G-protein coupled receptor signaling and extracellular matrix components for genes in the early up-late down dataset and their corresponding trends of change throughout the time course. Functional annotation was performed using DAVID gene ontology tool. Gene enrichment is based on the EASE Score (threshold p≤ 0.1), a modified Fisher Exact test used to measure gene enrichment in annotation terms in the DAVID system. The EASE score for each class is shown as the gene enrichment p-value.
| G-PROTEIN COUPLED RECEPTOR SIGNALING AND CELL SURFACE SIGNALING TRANSDUCTION | FOLD CHANGE RELATIVE TO CONTROL | ||||
|---|---|---|---|---|---|
| Enrichment p-value: 3.61E-06 | |||||
| Gene symbol | Gene Name | 1.5hrs | 3hrs | 6hrs | 12hrs |
| Gpr33 | G protein-coupled receptor 33 | 1.43 | 1.16 | 1.22 | 1.24 |
| Mrgprb2 | MAS-related G protein-coupled receptor, member X2-like; MAS-related GPR, member B2 | 1.25 | 1.16 | 1.13 | 1.11 |
| Rspo3 | R-spondin 3 homolog (Xenopus laevis) | 1.35 | 1.23 | 1.06 | −1.28 |
| Fpr1 | formyl peptide receptor 1 | 1.27 | 1.11 | 1.07 | 1.11 |
| Lef1 | lymphoid enhancer binding factor 1 | 1.21 | 1.35 | 1.05 | −1.08 |
| Olr104 | olfactory receptor 104 | 1.24 | 1.07 | 1.09 | 1.15 |
| Olr127 | olfactory receptor 127 | 1.27 | −1.04 | 1.10 | 1.08 |
| Olr145 | olfactory receptor 145 | 1.29 | 1.22 | 1.05 | 1.19 |
| Olr1515 | olfactory receptor 1515 | 1.24 | 1.18 | 1.04 | 1.16 |
| Olr190 | olfactory receptor 190 | 1.25 | 1.03 | −1.06 | 1.06 |
| Olr221 | olfactory receptor 221 | 1.22 | 1.10 | 1.06 | 1.12 |
| Olr259 | olfactory receptor 259 | 1.23 | 1.10 | 1.10 | 1.08 |
| Olr318 | olfactory receptor 318 | 1.24 | 1.13 | 1.09 | 1.18 |
| Olr379 | olfactory receptor 379 | 1.27 | 1.16 | 1.08 | 1.10 |
| Olr419 | olfactory receptor 419 | 1.23 | 1.17 | 1.07 | 1.09 |
| Olr446 | olfactory receptor 446 | 1.30 | 1.14 | 1.15 | 1.15 |
| Olr806 | olfactory receptor 806 | 1.25 | 1.19 | 1.12 | 1.27 |
| Olr851 | olfactory receptor 851 | 1.21 | 1.06 | 1.11 | 1.17 |
| Olr869 | olfactory receptor 869; olfactory receptor 862 | 1.28 | 1.14 | 1.21 | 1.15 |
| Olr877 | olfactory receptor 877 | 1.29 | 1.02 | 1.03 | 1.09 |
| Ptgir | prostaglandin I2 (prostacyclin) receptor | 1.24 | 1.17 | 1.14 | 1.13 |
| P2ry13 | purinergic receptor P2Y, G-protein coupled, 13 | 1.23 | 1.10 | 1.07 | 1.03 |
| Tas2r126 | taste receptor, type 2, member 126 | 1.24 | 1.14 | 1.18 | 1.24 |
| Taar7d | trace-amine-associated receptor 7d | 1.28 | 1.09 | 1.09 | 1.08 |
| EXTRACELLULAR MATRIX COMPONENTS AND CELL ADHESION | FOLD CHANGE RELATIVE TO CONTROL | ||||
| Enrichment p-value : 0.013095162 | |||||
| Gene symbol | Gene Name | 1.5hrs | 3hrs | 6hrs | 12hrs |
| Acan | aggrecan | 1.65 | 2.04 | 1.20 | −1.16 |
| Ang1 | angiogenin, ribonuclease A family, member 1 | 1.32 | 1.24 | 1.10 | 1.17 |
| Lamc2 | laminin, gamma 2 | 1.27 | 1.07 | 1.08 | 1.00 |
| Mmp10 | matrix metallopeptidase 10 | 1.22 | 1.10 | 1.03 | 1.06 |
| Nid2 | nidogen 2; similar to nidogen 2 protein | 1.22 | 1.29 | 1.00 | 1.03 |