Figure 10.
The top two fundus images were from the same rabbit eye that received RAP-loaded pSiO2-C8 particles. Left image was taken 1 week postinjection and the right image taken 8 weeks postinjection, showing clear view of fundus and RAP-loaded pSiO2-C8 particles in vitreous. The numbers of the particles were fewer in the 8-week image but still visible. The histology images from the 2-week (2wks) study (bottom left) and 8-week study (bottom right) were taken at visual streak, which is indicated by high density of ganglion cells. Compared with the left eye (OS), the study eyes (OD) did not show abnormality in retina and choroid. The separation of RPE from underneath choroid in the frame of 8wks OS was caused during tissue processing.