Table 2.

Pharmacokinetic Parameters for pSiO₂-C8-RAP Microparticle Formulation

Sample	R2	Half-life Lambda_z, d_	Tmax, d	Cmax, μg/mL	Clast, μg/mL	AUClast, μg·d/mL	AUCINF_pred, μg·d/mL
Free-RAP	0.76	1.95	1.00	511.83	3.04	2605.97	2608.89
SiO2-C8-RAP	0.96	4.14	3.00	2812.69	73.95	14810.77	15178.55

AUC_{INF_pred}, area under the concentration-time curve from time 0 to the predicted end time point by extrapolation; AUC_last, area under the concentration-time curve from time 0 to the last time point; C_last, drug concentration at the last observation time point; C_max, maximum concentration detected; T_max, time at which the concentration was maximum.