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. Author manuscript; available in PMC: 2015 Feb 16.
Published in final edited form as: Cell Rep. 2014 Jan 9;6(2):366–376. doi: 10.1016/j.celrep.2013.12.029

Figure 5. Role of the TSLP-TSLPR Axis in Der f/SEB-Induced Dermatitis and Spontaneous Dermatitis in Plcb3−/− Mice.

Figure 5

(A) Lesional skin from 10-month-old Plcb3−/− mice and healthy control (WT) were stained for TSLP (red) and nuclei (blue).

(B) Kaplan-Meier plots for dermatitis development in Plcb3−/−;TSLPR−/− (n = 10).

(C) Dermatitis was induced with Der f/SEB in WT, TSLPR−/− (T−/−), Plcb3−/− (b3−/−), and Plcb3−/−;TSLPR−/− (b3−/−;T−/−) mice.

(D) Histologic analysis of Der f/SEB-induced dermatitis. Data represent mean ± SEM.

(E and F) Kaplan-Meier plots for dermatitis development in Plcb3−/−;TNF−/− (n = 34), and Plcb3−/−;GM-CSF−/− (n = 31) mice.

Results in (C) and (D) are representative of two independent experiments using three to six mice per group. *p < 0.05, **p < 0.01, ***p < 0.001 by ANOVA. See also Figure S5.