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. 2014 Oct 28;58(3):1020–1037. doi: 10.1021/jm500810s

Table 2. Long Acting Pharmaceutical Formulations of GLP-1 Receptor Agonists.

formulation manufacturer/developer description ref
exenatide LAR AstraZeneca slow drug releasing subcutaneous depot with 1 entrapped noncovalently into a biodegradable PLGA microsphere (26)
microsphere Na et al. polysaccharide-based microsphere formulation of 1 (130)
hydrogel Ding et al. triblock copolymer PLGA-PEG-PLGA-based hydrogel formulation of 1 (131)
hydrogel Joabsson et al. lipid-based hydrogel preparation of GLP-1 and 1 for subcutaneous injection (132)
protease-operated depot (POD) Chilkoti et al. thermoresponsive depot forming elastin-like polymers containing protease-cleavable oligomers of [Gly8]-GLP-1(7–36) with a dipeptide (Gly-Ala) added at the N-terminus (133)
implantable device Kuzma et al. polymeric hydrogel-based implantable devices containing 1 (134)
formulation for pulmonary delivery Youn et al. albumin-coated porous hollow PLGA microparticles bound with palmitylated exendin-4 (135)
chewing gum tablet Andersen et al. chewing gum containing GLP-1 and exendin-4 (136)
formulation for gene therapy Kim et al. exenatide plasmid in an arginine-grafted bioreducible polymer (ABP) poly-cystaminebisacrylamidediaminohexane as the gene carrier (137)