Table 2. Summary of Other MDM2 Inhibitors.

entry	compd	MDM2 binding IC50	cell line; assay; IC50	PDB code	in vivo data	ref
1	15	80 nMa	MCF7; BrdU; 38 μM	1T4E		(53, 54)
2	16	394 nM	MCF7; BrdU; 1.1 μM			(55)
3	17	170 nM	SJSA-1; SRB; 5.2 μM			(56)
4	18	350 nM	SJSA-1; p21; 12 μM		PK data	(57)
5	19	>5 μM	MCF-7; MTT; 40 nM			(58)
6	20	9.2 nM		3VZV		(59)
7	21	58 nM	MV4;11; luminescent; 220 nM	3W69	PK and efficacy in SCID mice	(59)
8	22	30 nM		4DIJ		(60)
9	23	916 nMb		3LBK		(61)
10	24	130 nMb				(62)
11	25	150 nMb	A549; MTT; 1.97 μM		efficacy in nude mice	(63)
12	26	0.90 μM	SJSA-1; SRB; 102.3 μM			(64)
13	27	0.8 μMa				(61)
14	28	169 nM	SJSA-1; 4.7 μM			(65, 66)
15	29	41 nM	SJSA-1; 1 μM			(65, 66)
16	30	0.4 nM	SJSA-1; EdU; 25 nM	4OBA	PK and efficacy in nude mice	(67)
17	31	0.1 nM	SJSA-1; EdU; 16 nM	4ODE	PK and efficacy in nude mice	(68)
18	32	6 nM	av of three;c MTT; 15 nM		PK and efficacy in nude mice	(69)
19	33	7 nM	av of three;c MTT; 7 nM	4LWV	PK and efficacy in nude mice	(69)

^aBinding affinity was measured as K_d;

^bBinding affinity was measured as K_i

^cAverage of three cell lines SJSA-1, HCT116, and RKO