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. Author manuscript; available in PMC: 2015 Feb 16.
Published in final edited form as: Inflamm Bowel Dis. 2013 Mar;19(3):512–525. doi: 10.1097/MIB.0b013e31828028ad

Figure 5. Colonic expression of Stat3 target genes that mediate epithelial restitution is decreased while SOCS3, IFN-γ, and IL-17A expression are increased in Stat3ΔIEC mice at Day 28.

Figure 5

Real-time RT-PCR was performed on mRNA isolated from whole colonic serial sections for (A) Reg3β, Reg3γ, SOCS3 (B) IL-6, IL-10, IL-17A (C) IFN-γ, IL-4, IL-1β, and TNF-α expression in Stat3Flx/Flx littermate controls and Stat3ΔIEC mice at day 0, day 7, and day 28 (n>5 mice per genotype). Data are normalized to β-actin mRNA expression and expressed as fold change to Stat3Flx/Flx day 0 littermate controls shown as mean + SEM. Differences between genotypes at day 0 and day 28 were compared by unpaired t-test (*, p < .05; ** p < .005; *** p < .0001).