Figure 7. Colonic expression of IL-6, IL-10, IFN-y and IL-17A correlates with histologic severity and IL-17A expression correlates with the frequency of colon pSTAT3+CD3+ T-lymphocytes in Stat3ΔIEC mice at day 28.
Pearson regression analysis was used to test for an association between normalized colonic expression of (A) IL-6 (B) IL-10 (C) IFNγ and (D) IL-17A and histologic severity score. E) Pearson regression analysis was used to test for an association between IL-17A colonic expression and the frequency of CD3+/pSTAT3+ T-lymphocytes per 400x high-powered field (r=.90, p<.002) (n>7 mice per genotype). Data are shown as mean + SEM (*, p < .05; ** p < .005; *** p < .0001 by unpaired t-test).