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. 2015 Feb 9;10:1045–1059. doi: 10.2147/IJN.S73303

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© 2015 Tan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Peptide (IK8L) decreased mortality rates and disease severity in Kp-infected mice.

Notes: (A) Whole animal imaging of bioluminescence was obtained using IVIS XRII system at different time points. Sham- and IK8L-treated mice were infected with 1×10⁵ CFU of Kp Xen-39 by nasal cavity (Caliper) (arrows indicating Kp spread regions). (B) Kaplan–Meier survival curves were obtained (P=0.0455; 95% confidence interval: 1.041 to 52.46, log-rank test). (C) Bacterial burdens (CFU) of Kp-infected mice treated with IK8L or control at different times. In (A), data are shown as mean ± SD/SEM of n=4 mice per group; (A–C) are representative of four mice per group. ***P<0.001; Mann–Whitney U-test.

Abbreviations: CFU, colony-forming units; h, hours; Kp Xen-39, ; Max, maximum; Min, minimum; RLU, relative LUC units; LUC, luminescence unit counts; SD, standard deviation; SEM, standard error of the mean.