Figure 3.

IK8L decreased infection-induced tissue injury.

Notes: (A) Morphological evidence of lung injury and inflammatory responses as assessed by H&E staining histological analysis (20×, scale bar =50 μm, inset shows the typical tissue injury and inflammatory influx). (B–E) Decreased MPO in the lung, kidney, spleen, and liver of IK8L-treated mice. Data are shown as mean ± SEM of n=3 mice per group and are representative of three independent experiments. *P<0.05; **P<0.01; ***P<0.001; one-way ANOVA (Tukey’s post hoc).

Abbreviations: ANOVA, analysis of variance; h, hours; H&E, hematoxylin and eosin; MPO, myeloperoxidase; RLU, relative LUC units; SEM, standard error of the mean.