Table 4.
Cochrane Risk of Bias Assessment Tool
| Study | Adequate Sequence Generation | Allocation Concealment | Blinding | Incomplete Outcome Data | Free of Selective Reporting |
|---|---|---|---|---|---|
| ECHO CRT11 | Computer generated randomization | Yes | Double Blind | Intentional to treat analysis; low discontinuation | Yes |
| LESSER‐EARTH12 | Randomized, no further details | Yes | Double Blind | Intentional to treat analysis; low discontinuation | Yes |
| RethinQ17 | Computer generated randomization | Yes | Double Blind | Intentional to treat analysis; low discontinuation | Yes |
| NARROW‐CRT10 | Block randomization; Delivered by sealed envelope technique | Insufficient detail | Patients blinded | Insufficient details | Only echocardiographic parameters from CRT arm presented |
| RESPOND8 | Computer generated randomization; Delivered by sealed envelope technique | Insufficient detail | Unblinded | Intentional to treat analysis; low discontinuation | Yes |
| Achilli et al16 | Effectively single arm with non‐comparable wide QRS group | Open label | Unblinded | Insufficient details | Yes |
| Bleeker et al18 | Effectively single arm with non‐comparable control group | Open label | Unblinded | Insufficient details | Yes |
| ESTEEM‐CRT7 | Single Arm | Not applicable | Unblinded | Insufficient details | Yes |
| PROSPECT14 | Single Arm | Not applicable | Unblinded | Insufficient details | Yes |
| Gasparini et al9 | Effectively single arm with non‐comparable wide QRS group | Open label | Unblinded | Insufficient details | Yes |
| van Bommel13 | Single Arm | Not applicable | Unblinded | Insufficient details | Yes |
| Yu et al15 | Effectively single arm with non‐comparable wide QRS group | Open label | Unblinded | Insufficient details | Yes |