Table 8.
Association of Cardiac Hemodynamic Measures With Depression and cognitive impairment: AGES‐RS Imaging Cardiac Evaluation to Locate Areas of Necrosis and Detect MI (ICELAND‐MI)
| Depression | Cognitive Impairment* | |||
|---|---|---|---|---|
| OR* (95% CI) | P Value | OR* (95% CI) | P Value | |
| LVEF | ||||
| Model 1 | 1.11 (0.81, 1.51) | 0.49 | 1.17 (0.88, 1.56) | 0.25 |
| Model 2 | 1.10 (0.77, 1.56) | 0.60 | 1.02 (0.75, 1.38) | 0.89 |
| LVSV | ||||
| Model 1 | 0.93 (0.76, 1.16) | 0.52 | 1.28 (1.03, 1.58) | 0.026 |
| Model 2 | 0.86 (0.68, 1.09) | 0.22 | 1.24 (0.99, 1.57) | 0.070 |
| CO | ||||
| Model 1 | 0.96 (0.64, 1.14) | 0.29 | 1.51 (1.07, 2.12) | 0.018 |
| Model 2 | 0.79 (0.57, 1.07) | 0.13 | 1.40 (0.99, 2.00) | 0.067 |
Model 1: adjusted for age and sex; Model 2: adjusted for age, sex, education, current smoker, history of hypertension, diabetes mellitus, systolic blood pressure, prevalent coronary heart disease, stroke, total cholesterol, body mass index, atrial fibrillation. AGES‐RS indicates age, gene/environment susceptibility‐Reykjavik Study; CO, cardiac output; LVEF, left ventricular ejection fraction; LVSV, left ventricular stroke volume; MI, myocardial infarction.
Defined as mild cognitive impairment or dementia.
Betas and odds ratios are presented for each 10% lower LVEF, 10 mL lower LVSV and 1 L/min lower CO.