Table 6.
Effect of Diets on Lipoprotein Particle Size and Subclasses (Particle Number From NMR Lipoprofile)
| Lipoprotein Particle | Baseline AAD (n=45) | LF (n=43) | MF (n=42) | AV (n=43) | Treatment Effect (P Value) |
|---|---|---|---|---|---|
| LDL‐P, nmol/L | |||||
| Total | 1145.7±32.5 | 1168.1±38.3a | 1099.7±32.3b | 1054.6±31.4c* | <0.0001 |
| Large | 476.8±25.9 | 399.7±28.8* | 407.0±26.4* | 408.6±20.2* | 0.7 |
| Small | 557.3±32.5 | 666.5±41.5a* | 615.9±34.7b* | 561.5±31.6c | <0.0001 |
| IDL‐P, nmol/L | 111.6±8.7 | 102.0±9.3a | 76.8±6.2b* | 84.4±7.9b* | 0.0005 |
| VLDL‐P, nmol/L | |||||
| Total | 62.2±3.9 | 66.7±4.4a | 59.6±3.9a,b | 55.2±4.3b | 0.02 |
| Large | 2.9±0.4 | 4.5±0.8a* | 2.5±0.3b | 2.7±0.4b | 0.001 |
| Medium | 24.2±2.3 | 31.3±3.1a* | 24.3±2.5b | 23.5±3.1b | 0.02 |
| Small | 35.2±2.1 | 30.9±2.2* | 32.9±2.0* | 29.0±2.1* | 0.1 |
| HDL‐P, nmol/L | |||||
| Total | 30.7±0.7 | 31.3±0.7 | 31.4±0.7 | 31.4±0.6 | 0.7 |
| Large | 5.1±0.4 | 4.3±0.3* | 4.6±0.4* | 4.6±0.3* | 0.2 |
| Medium | 10.3±0.6 | 12.2±0.8* | 11.0±0.7* | 10.9±0.7* | 0.5 |
| Small | 15.3±0.5 | 14.8±0.6a | 15.9±0.5b | 15.9±0.6a,b | 0.04 |
| Average particle size, nm | |||||
| LDL | 20.87±0.08 | 20.62±0.09a* | 20.65±0.08a,b* | 20.74±0.08b* | 0.03 |
| VLDL | 44.62±0.73 | 47.18±0.98a* | 45.04±0.62b | 45.41±0.68a,b | 0.02 |
| HDL | 9.04±0.06 | 8.96±0.05* | 8.94±0.06* | 8.98±0.06* | 0.1 |
All values are means±SEMs. AAD indicates average American diet; AV, avocado diet; HDL‐P, high‐density lipoprotein particle number; IDL‐P, intermediate‐density lipoprotein particle number; LDL‐P, low‐density lipoprotein particle number; LF, lower‐fat diet; MF, moderate‐fat diet; VLDL‐P, very‐low‐density lipoprotein particle number.
*
Significant change compared to baseline AAD, P<0.05; Values in diet treatments with different superscript letters (a, b, and c) are significantly different (Tukey post‐hoc test by SAS, P<0.05).