Table 7.
Effect of Diets on Lipoprotein Subclasses (Cholesterol Concentration From VAP Test)
| Baseline AAD (n=45) | LF (n=43) | MF (n=42) | AV (n=43) | Treatment Effect (P Value) | |
|---|---|---|---|---|---|
| LDL‐C, mg/dL | |||||
| LDL1 | 21.3±1.2 | 19.4±1.1a | 18.4±0.9a,b* | 17.9±1.0b* | 0.03 |
| LDL2 | 29.7±2.0 | 24.7±2.5* | 25.2±2.1* | 25.4±2.2* | 0.6 |
| LDL3 | 44.5±2.4 | 42.2±2.3a,b | 43.4±1.9b | 40.0±2.0a* | 0.01 |
| LDL4 | 10.4±1.3 | 12.6±1.6a* | 11.2±1.4a,b | 10.5±1.3b | 0.04 |
| LDL1+2 | 51.0±2.8 | 44.1±3.3* | 43.6±2.7* | 43.2±2.9* | 0.9 |
| LDL3+4 | 55.0±3.3 | 54.9±3.5a | 54.6±3.0a | 50.5±3.1b* | 0.01 |
| LDL peak max time, s | 117.0±0.5 | 115.8±0.6* | 116.2±0.5* | 116.4±0.6 | 0.4 |
| HDL‐C, mg/dL | |||||
| HDL2 | 11.6±0.7 | 10.5±0.6* | 10.9±0.6* | 10.8±0.6* | 0.6 |
| HDL3 | 36.9±1.1 | 34.2±0.9a* | 36.1±1.0b | 36.0±1.0b | 0.01 |
| VLDL‐C, mg/dL | |||||
| VLDL1+2 | 9.9±0.5 | 11.3±0.8a* | 9.5±0.5b | 9.1±0.5b | <0.0001 |
| VLDL3 | 13.3±0.4 | 14.2±0.5a* | 13.1±0.5b | 12.6±0.4b | <0.0001 |
| IDL‐C, mg/dL | |||||
| IDL1 | 4.3±0.3 | 4.7±0.3a* | 4.2±0.3b | 3.9±0.2b | <0.0001 |
| IDL2 | 11.4±0.5 | 11.1±0.5a | 10.5±0.6a,b | 9.8±0.5b* | 0.0005 |
| Remnant Lp, mg/dL | 29.0±1.1 | 30.0±1.1a* | 27.8±1.2b | 26.3±1.0b* | <0.0001 |
All values are means±SEMs. AAD indicates average American diet; AV, avocado diet; HDL, high‐density lipoprotein; IDL‐C, intermediate‐density lipoprotein cholesterol; LDL, low‐density lipoprotein; LF, lower‐fat diet; MF, moderate‐fat diet; Remnant Lp, lipoprotein remnants; VAP, vertical auto profile; VLDL‐C, very‐low‐density lipoprotein cholesterol.
*
Significant change compared to baseline AAD, P<0.05; Values in diet treatments with different superscript letters (a/b) are significantly different (Tukey post‐hoc test by SAS, P<0.05).