Table 4.
Univariate and Multivariate Analysis of Risk Factors of Ventricular Fibrillation
| Variable | Contrast | Univariate | Multivariate* | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | ||
| Younger age | Aged <60 years vs ≥60 years | 1.38 | 0.99 to 1.90 | 0.050 | 1.75 | 1.20 to 2.60 | 0.005 |
| Male sex | Male vs female | 1.90 | 1.21 to 2.95 | 0.005 | 1.65 | 0.98 to 2.75 | 0.060 |
| Alcohol | |||||||
| 1 to 7 units/week | Nondrinkers | 1.30 | 0.83 to 2.05 | 0.300 | 1.30 | 0.80 to 2.20 | 0.300 |
| 8 to 14 units/week | Nondrinkers | 1.94 | 1.12 to 3.37 | 0.020 | 2.30 | 1.20 to 4.20 | 0.008 |
| ≥15 units/week | Nondrinkers | 3.25 | 1.93 to 5.50 | <0.001 | 3.30 | 1.80 to 5.90 | <0.001 |
| Atrial fibrillation | Yes vs no | 2.94 | 1.29 to 6.73 | 0.010 | 2.80 | 1.10 to 7.30 | 0.040 |
| Preinfarction angina | Yes vs no | 0.53 | 0.38 to 0.73 | <0.001 | 0.46 | 0.32 to 0.67 | <0.001 |
| FH of sudden death | Yes vs no | 1.80 | 1.27 to 2.56 | 0.001 | 1.60 | 1.10 to 2.40 | 0.010 |
| Infarct location | Anterior vs nonanterior | 1.55 | 1.10 to 2.10 | 0.009 | 2.10 | 1.40 to 3.00 | <0.001 |
| TIMI flow before PPCI | TIMI flow grade 0 vs grade 1 to 3 | 1.35 | 0.97 to 1.90 | 0.070 | 1.65 | 1.14 to 2.40 | 0.008 |
| Statins before STEMI | Yes vs no | 2.05 | 1.34 to 3.15 | 0.001 | 2.10 | 1.15 to 4.0 | 0.020 |
| Hypercholesterolemia | Yes vs no | 1.40 | 1.00 to 1.95 | 0.050 | 0.90 | 0.55 to 1.50 | 0.800 |
| Hypertension | Yes vs no | 1.39 | 0.99 to 1.94 | 0.050 | 1.20 | 0.79 to 1.85 | 0.400 |
| Smoking | |||||||
| Past | Past vs never | 1.48 | 0.90 to 2.40 | 0.100 | 1.18 | 0.68 to 2.00 | 0.600 |
| Current | Current vs never | 1.30 | 0.83 to 2.00 | 0.300 | 1.10 | 0.66 to 1.85 | 0.700 |
| Study site | 1.00 | 0.87 to 1.12 | 0.900 | 1.00 | 0.87 to 1.15 | 1.000 | |
FH indicates family history; OR, odds ratio; PPCI, primary percutaneous coronary intervention; STEMI, ST‐segment elevation myocardial infarction; TIMI, thrombolysis in myocardial infarction.
219 cases and 441 controls were included from the 4 centers.
*
200 cases and 431 controls from the 4 centers included in the full multivariable model. Because the ratio of cases to controls did differ at each of the sites, we added a variable study site to the multivariable model to control for any unmeasured differences between cases and controls enrolled at each of the 4 centers.